Protein Details: Potassium voltage-gated channel subfamily KQT member 3
Protein ID
ICDB_Pro_0640
Protein Name
Potassium voltage-gated channel subfamily KQT member 3
Gene Name
KCNQ3
Organism
Bos taurus (Bovine)
Length
866 amino acids
AlphaFoldDB
AF-P58126-F1-model_v4.pdb
Function
Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current; a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore; it is important in the regulation of neuronal excitability. KCNQ2-KCNQ3 channel is selectively permeable to other cations besides potassium; in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+). Associates with Na(+)-coupled myo-inositol symporter SLC5A3 forming a coregulatory complex that alters ion selectivity; increasing Na(+) and Cs(+) permeation relative to K(+) permeation
Sequence
PDB Structures
Ligand Binding
Binding Site
Disease
Location
DOI ID
RefSeq
NP_776799.1